Hitting an Invisible Target in TB Vaccine Design

I have a troubled relationship with Twitter. It’s an unredeemable hate sort of thing. I’m generally an inane mix of angry opinion and low self-esteem so, in theory, we’re perfect for each other. I just don’t feel it, though. I had a quick look for online videos in the same vein of the YouTube self-hypnosis that resolutely failed...

Rebranding Tuberculosis

If infectious diseases were monsters, what would they look like? I imagine malaria would be a terrible mosquito-like creature made of bones, with a wickedly sharp proboscis and a throbbing gut of fiery red blood. Diarrhoeal disease would rise from a swamp of sewage, grinning with its skull’s jaw as it handed out cups of contaminated...

Refocusing the Microscope

I grew up staring out at the stars through my parents’ antique telescopes; marvelling at the tiny pinpricks of twinkling light and how, on a clear night, the Milky Way streaked across the sky. There are more than 100 billion stars in our galaxy, and more than 1,000 billion galaxies in the universe. How many of them, I used to...

When Bad Bugs Go Badder

The Beijing lineage of M. tuberculosis is the villain in a movie sequel. Nastier, scarier, harder to kill. You thought tuberculosis (TB) was bad? Think again. The Beijing lineage is that little bit worse, associated with a speedier disease progression and increased antibiotic resistance. I’ve always had a thing for studies...

The Missing Three Million

In Agra’s slums, community volunteers are visiting the houses one-by-one and asking the occupants a simple question: “Have you been coughing for more than two weeks?” Of the ten million new cases of TB every year, one-third remain invisible to the public health authorities. India currently holds the dubious title of World’s...

Blame the Europeans

You know when you drive an unfamiliar car and you have to find your way round all these knobs and buttons to make the car go in the direction you want it to go in? M. tuberculosis has the same problem when it comes to the human immune system. This can make things tricky as it’s a pathogen that practices immune subversion rather...

Wasted Time Isn’t Always Wasted Time

The other day I commented to the father of my child that having a baby is a little bit like going to prison. Not the ‘nice’ sort of prison where they let you do Open University courses and try to make you a better person. A Victorian-style prison where the inmates are forced to turn a crank thousands of times a day or walk on...